Mysterious Liquid: the tear appearance is reset back to normal, but tears will still leave green creep on the ground.Fire Mind: the tear appearance is reset back to normal, but tears can still explode when they hit an enemy.
Cupid's Arrow: the tear appearance is reset back to normal, but the tears still travel through enemies.1up!: the mushroom familiar continues to follow Isaac, but doesn't grant an extra life.Items that grant flight: Isaac's appearance is reset back to normal, but he is still able to fly.Some items behave unusually after leaving the room while the Holy Mantle shield was active:.Continuum, Epic Fetus, Eve's Mascara, Godhead, Ipecac, Jacob's Ladder, The Ludovico Technique, A Lump of Coal, Monstro's Lung, My Reflection, Ouija Board, Pop!, Rubber Cement, Sacred Heart, Spoon Bender, Strange Attractor, Technology Zero.Some tear effects from items will remain active between rooms.For example, the tears down applied from The Inner Eye will persist between rooms, but Isaac will not shoot three tears at once. Items that modify your stats and have other additional effects will keep the stats but the effect will be gone after leaving the room. Blanket / Holy Card / Holy Mantle / Wooden Cross: if Metronome is used while the shield is active, any stat changes or familiars/orbitals generated from Metronome will persist between rooms until Metronome is used again or replaced with another active item.Rock Bottom: Isaac keeps any stat upgrades gained by a random temporary item as long as the item brings his stats over their highest value reached on that run.If a passive item was selected, grants any random wisp. Book of Virtues: If an active item was selected, grants the same wisp as that item.Metronome has a reduced chance of activating Genesis (25% success) or Death Certificate (15% success).If Metronome triggers the effect of Genesis, it will disappear from the active slot, just as with the real item.If Metronome triggers the effect of Moving Box, items in the room will be packed away into the box until you either find the Moving Box or Metronome gives you the Moving Box effect again (unlikely).Keep in mind that you can trigger items you haven't unlocked yet, which means you could trigger the effect of items like Death Certificate without having to go through the trouble of unlocking them.
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